In certain embodiments, pharmaceutical compositions comprising a compound of Formula 1 may be administered to treat cancer in a subject so as to provide a therapeutically effective concentration of a compound of Formula 1 in the blood or plasma of a subject for an extended period of time such as, for example, for at least about 4 hours, for at least about 6 hours, for at least about 8 hours, for at least about 10 hours, and in certain embodiments, for at least about 12 hours priligy otc This abnormal myocardial velocity pattern is suggestive of diastolic dysfunction in the woman with preeclampsia